Delivery of Prazosin Hydrochloride from Osmotic Pump System Prepared by Coating the Core Tablet with an Indentation
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چکیده
منابع مشابه
Novel osmotic pump tablet using core of drug-resin complexes for time-controlled delivery system.
A novel elementary osmotic pump tablet was developed. The system uses the core of drug-resin complexes (DRCs) loaded with propranolol hydrochloride (PNH) for time-controlled delivery. In traditional osmotic pump tablets (OPTs), the lag time was always minimized. However, in the DRCs osmotic pump tablet (DRCOPT), the lag time was increased to achieve the time-controlled delivery. The quantity of...
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the aim of the current study was to design a porous osmotic pump–based drug delivery system for controlling the release of buspirone from the delivery system. the osmotic pump was successfully developed using symmetric membrane coating. the core of the tablets was prepared by direct compression technique and coated using dip-coating technique. drug release from the osmotic system was studied us...
متن کاملOsmotic Pump Drug Delivery- a Novel Approach
Conventional drug delivery systems have little control over their drug release and almost no control over the effective concentration at the target site. The major problem associated with conventional drug delivery system is unpredictable plasma concentrations. Osmotic devices are the most promising strategy based systems for controlled drug delivery. They are the most reliable controlled drug ...
متن کاملDevelopment of an osmotic pump system for controlled delivery of diclofenac sodium.
Based on an elementary osmotic pump, controlled release systems of diclofenac sodium (DS) were designed to deliver the drug in a zero-order release pattern. Osmotic pump tablets containing 100 mg DS were prepared and coated with either semipermeable (SPM) or microporous (PM) membranes. The tablet coats were composed of hydrophobic triacetin (TA) or hydrophilic polyethylene glycol 400 (PEG 400) ...
متن کاملDevelopment and evaluation of microporous osmotic tablets of diltiazem hydrochloride
Microporous osmotic tablet of diltiazem hydrochloride was developed for colon targeting. These prepared microporous osmotic pump tablet did not require laser drilling to deliver the drug to the specific site of action. The tablets were prepared by wet granulation method. The prepared tablets were coated with microporous semipermeable membrane and enteric polymer using conventional pan coating p...
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ژورنال
عنوان ژورنال: Drug Delivery
سال: 2007
ISSN: 1071-7544,1521-0464
DOI: 10.1080/10717540601067455